MT1 receptor (mtr1a_human)
FAMILY
Class A (Rhodopsin) Melatonin receptors Melatonin MT1 receptor
GENE
MTNR1A
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Melatonin receptor type 1A, Mel-1A-R, Mel1a receptor
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
Q
|
G
|
N
|
G
|
S
|
A
|
L
|
P
|
N
|
10 |
A
|
S
|
Q
|
P
|
V
|
L
|
R
|
G
|
D
|
G
|
20 |
TM1 | |||||||||
A
|
R
|
P
|
S
|
W
|
L
|
A
|
S
|
A
|
L
|
30 |
A
|
C
|
V
|
L
|
I
|
F
|
T
|
I
|
V
|
V
|
40 |
D
|
I
|
L
|
G
|
N
|
L
|
L
|
V
|
I
|
L
|
50 |
ICL1 | |||||||||
S
|
V
|
Y
|
R
|
N
|
K
|
K
|
L
|
R
|
N
|
60 |
TM2 | |||||||||
A
|
G
|
N
|
I
|
F
|
V
|
V
|
S
|
L
|
A
|
70 |
V
|
A
|
D
|
L
|
V
|
V
|
A
|
I
|
Y
|
P
|
80 |
Y
|
P
|
L
|
V
|
L
|
M
|
S
|
I
|
F
|
N
|
90 |
ECL1 | TM3 | ||||||||
N
|
G
|
W
|
N
|
L
|
G
|
Y
|
L
|
H
|
C
|
100 |
Q
|
V
|
S
|
G
|
F
|
L
|
M
|
G
|
L
|
S
|
110 |
V
|
I
|
G
|
S
|
I
|
F
|
N
|
I
|
T
|
G
|
120 |
I
|
A
|
I
|
N
|
R
|
Y
|
C
|
Y
|
I
|
C
|
130 |
ICL2 | |||||||||
H
|
S
|
L
|
K
|
Y
|
D
|
K
|
L
|
Y
|
S
|
140 |
TM4 | |||||||||
S
|
K
|
N
|
S
|
L
|
C
|
Y
|
V
|
L
|
L
|
150 |
I
|
W
|
L
|
L
|
T
|
L
|
A
|
A
|
V
|
L
|
160 |
ECL2 | |||||||||
P
|
N
|
L
|
R
|
A
|
G
|
T
|
L
|
Q
|
Y
|
170 |
D
|
P
|
R
|
I
|
Y
|
S
|
C
|
T
|
F
|
A
|
180 |
TM5 | |||||||||
Q
|
S
|
V
|
S
|
S
|
A
|
Y
|
T
|
I
|
A
|
190 |
V
|
V
|
V
|
F
|
H
|
F
|
L
|
V
|
P
|
M
|
200 |
I
|
I
|
V
|
I
|
F
|
C
|
Y
|
L
|
R
|
I
|
210 |
W
|
I
|
L
|
V
|
L
|
Q
|
V
|
R
|
Q
|
R
|
220 |
ICL3 | TM6 | ||||||||
V
|
K
|
P
|
D
|
R
|
K
|
P
|
K
|
L
|
K
|
230 |
P
|
Q
|
D
|
F
|
R
|
N
|
F
|
V
|
T
|
M
|
240 |
F
|
V
|
V
|
F
|
V
|
L
|
F
|
A
|
I
|
C
|
250 |
W
|
A
|
P
|
L
|
N
|
F
|
I
|
G
|
L
|
A
|
260 |
ECL3 | |||||||||
V
|
A
|
S
|
D
|
P
|
A
|
S
|
M
|
V
|
P
|
270 |
TM7 | |||||||||
R
|
I
|
P
|
E
|
W
|
L
|
F
|
V
|
A
|
S
|
280 |
Y
|
Y
|
M
|
A
|
Y
|
F
|
N
|
S
|
C
|
L
|
290 |
H8 | |||||||||
N
|
A
|
I
|
I
|
Y
|
G
|
L
|
L
|
N
|
Q
|
300 |
N
|
F
|
R
|
K
|
E
|
Y
|
R
|
R
|
I
|
I
|
310 |
V
|
S
|
L
|
C
|
T
|
A
|
R
|
V
|
F
|
F
|
320 |
C-term | |||||||||
V
|
D
|
S
|
S
|
N
|
D
|
V
|
A
|
D
|
R
|
330 |
V
|
K
|
W
|
K
|
P
|
S
|
P
|
L
|
M
|
T
|
340 |
N
|
N
|
N
|
V
|
V
|
K
|
V
|
D
|
S
|
V
|
350 |
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
melatonin